Nutrition modulation of human aging: The calorie restriction paradigm
نویسندگان
چکیده
منابع مشابه
Aging, adiposity, and calorie restriction.
CONTEXT Excessive calorie intake and subsequent obesity increases the risk of developing chronic disease and decreases life expectancy. In rodent models, calorie restriction with adequate nutrient intake decreases the risk of developing chronic disease and extends maximum life span. OBJECTIVE To evaluate the physiological and clinical implications of calorie restriction with adequate nutrient...
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In the 75 years since the seminal observation of Clive McCay that restriction of calorie intake extends the lifespan of rats, a great deal has been learned about the effects of calorie restriction (CR; reduced intake of a nutritious diet) on aging in various short-lived animal models. Studies have demonstrated many beneficial effects of CR on health, the rate of aging, and longevity. Two prospe...
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Calorie restriction (CR) without malnutrition slows aging and increase average and maximal lifespan in model organisms and rodents. In human and non-human primates, CR has beneficial effects on human longevity and reduces the incidence of age-related diseases such as obesity, diabetes mellitus hypertension, cardiovascular disease and cancer. CR exerts its anti-aging effects through different me...
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ژورنال
عنوان ژورنال: Molecular and Cellular Endocrinology
سال: 2017
ISSN: 0303-7207
DOI: 10.1016/j.mce.2017.04.011